Virilizing adrenal carcinoma in two sibs.
نویسندگان
چکیده
Though the familial occurrence of virilization associated with hyperplasia of the adrenal cortex has long been established, there have been only two reports of the familial aggregation of virilizing adrenal carcinoma. It is the purpose of the present communication to describe a family in which 2 sibs, who were products of a consanguineous marriage, had virilizing tumours ofthe adrenal cortex proved histologically.
منابع مشابه
Birthweight in congenital virilizing adrenal hyperplasia.
The deficiency of C-21-hydroxylation in adrenocorticosteroid synthesis is the commonest cause of congenital virilizing adrenal hyperplasia (CVAH). Abnormal secretory activity in CVAH begins about the third month of gestation before the differentiation of external genitalia (Bierich, 1963). The masculinization of the female external genitalia noted at birth in almost all cases is thought to resu...
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Context: Mild forms of simple virilizing congenital adrenal hyperplasia (CAH) may be missed in newborn screening. In the pre-newborn-screening era, missed diagnosis of simple virilizing CAH was not infrequent in boys. Elevated adrenal androgens lead to accelerated growth and bone maturation. Traditional treatment of CAH consists of the suppression of ACTH through glucocorticoid replacement, in ...
متن کاملGrowth pattern of untreated boys with simple virilizing congenital adrenal hyperplasia indicates relative androgen insensitivity during the first six months of life.
CONTEXT Mild forms of simple virilizing congenital adrenal hyperplasia (CAH) may be missed in newborn screening. In the pre-newborn-screening era, missed diagnosis of simple virilizing CAH was not infrequent in boys. Elevated adrenal androgens lead to accelerated growth and bone maturation. Traditional treatment of CAH consists of the suppression of ACTH through glucocorticoid replacement, in a...
متن کاملA case of virilzing adrenocortical carcinoma diagnosed by urine steroid profiling
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 8 2 شماره
صفحات -
تاریخ انتشار 1971